DeCuya even though there should be no issue at all upgrading to the latest version, we'll provide clear upgrade instructions.
You also have to keep in mind that some extensions might be made compatible to this latest version later or not at all, so rely on those that you can expect to be actively maintained.
And one more thing, being beta software means you might need to dive into your database to do manual fixes, this is a generic warning that only occasionally has been required of webmasters in very specific, isolated situations.